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Dr. Ambadas B. Rode

Assistant Professor
E-mail: ab.rode at rcb dot res dot in

  • PhD 2012, Kongju National University, Republic of Korea
  • Postdoc, Frontier Institute for Biomolecular Engineering Research, Konan University, Kobe, Japan
  • Research Assistant Professor Fellow, Frontier Institute for Biomolecular Engineering Research,
    Konan University, Kobe, Japan

Targeting and tuning nucleic acid structures for therapeutic and biotechnology applications

Nucleic acids are essential macromolecules in living cells. Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) have inherent ability to form diverse tertiary structures such as triplex, G-quadruplex, and riboswitch etc., through non-canonical base-pairings. These structures contain additional instructions to control the fundamental cellular processes such as DNA replication, transcription, and translation etc. The nucleic acids structure mediated changes in levels of gene expression are associated with many human diseases including cancer. Thus, nucleic acid structures have emerged as potential therapeutic targets for various diseases. In addition, modular nature of nucleic acids makes it a promising building material for construction of tools such as synthetic switches for solving the problems in medicine and biotechnology.

Our group uses synthetic organic chemistry, molecular biology and biophysical chemistry techniques to get insights into the nucleic acids structure-function relationship in human and bacteria. Next, we apply this obtained knowledge to develop synthetic molecules to target the nucleic acid structures for therapy or to develop synthetic nucleic acids tools to solve problems in biotechnology.

  • Ramalingaswami Re-entry Fellowship (2017).
  • Ramanujan Fellowship (2017).
  • JSPS Postdoctoral Fellowship (2015).
  • The Chemical Society of Japan (CSJ) Oral Presentation Award for the presentation at 97th Annual meeting of the chemical Society of Japan (2017).
  • ISNAC Outstanding Oral Presentation Award for the presentation at 43th International Symposium on Nucleic Acids Chemistry, Japan (2016).
  • ISNAC Outstanding Poster Presentation Award for the presentation at 40th International Symposium on Nucleic Acids Chemistry, Japan (Nov 2013).
  • SPARC Award at a Pharma Company (MNC) Pune, Maharashtra, India (Jan 2008).
  • Subhashini Sahu
    Junior Research Fellow
    subhashni.sahu@rcb.res.in
  • Divya Ojha
    Project Assistant
    divya.ojha@rcb.res.in

Dr. Ambadas B. Rode
Regional Centre for Biotechnology
NCR Biotech Science Cluster
3rd Milestone, Faridabad-Gurgaon Expressway
P.O. Box No. 3, Faridabad - 121 001
Haryana (NCR Delhi), India
E-mail: ab.rode at rcb dot res dot in
Phone: 91 129-2848788

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