Dr. Avinash Bajaj
Professor
  • PhD 2008, Indian Institute of Science
  • Postdoc at University of Massachusetts, USA
bajaj[at]rcb[dot]res[dot]in
Lab website: https://www.avinashlab.net

Laboratory of TIME 

(Tumour Immune Microenvironment)

Cancer patients show differential responses to existing chemotherapy and immunotherapy regimens due to the presence of complex tumour immune microenvironments (TIME). This complex TIME features immune cells, stromal cells, nerve cells, blood vessels and extracellular matrix that maintain cordial relationships with cancer cells, supporting their survival, growth and spread. Multiple secretory factors, including chemokines, cytokines, and metabolites, build an immunosuppressive tumour microenvironment (TME) by inhibiting the T cell-mediated antitumour immunity and by enhancing the infiltration of immunosuppressive tumour-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs) and T-regulatory cells (Treg). Therefore, there is always a tug-of-war between immunosuppression dominated by tumour-associated macrophages, T-regulatory cells, myeloid-derived suppressor cells, and T-cell immunity that includes activated dendritic cells and cytotoxic T cells. 

 We aim to build multiple strategies that can tilt the balance of this tug-of-war towards T cell immunity against cancer, especially breast and colorectal (CRC) cancer. 

To build these strategies, we are running the following programs:

Deciphering the Role of Cancer Metabolism on TIME

One of the major challenges to the poor efficacy of the current therapeutic regimens for cancer treatment is the immunosuppressive TIME that inhibits the efficacy of chemotherapy and immunotherapy regimens. Another major challenge is the inability of the current therapeutic regimens to target metastatic tumours. Therefore, there is a need to develop therapeutic regimens that can mitigate immunosuppressive TIME and clear metastatic tumours. In addition to the genomic, phenotypic, and molecular diversity observed among various cancer types, metabolism has emerged as a key hallmark influencing the pathophysiology of cancer, particularly following the identification of the Warburg effect. Recent insights into tumour metabolism indicate that metabolic alterations not only influence the activation of oncogenes and the inactivation of tumour suppressor genes but also contribute to immunosuppression by inhibiting T-cell activity and diminishing the effectiveness of immune checkpoint blockade therapy. Therefore, we aim to decipher the impact of altered cellular metabolism on TIME and identify the key therapeutic targets for modulating TIME.

 

Elucidating the Role of Neurons on TIME

Neurons crosstalk with cancer cells and other stromal cells, including immune cells, in the TME through neurotrophic factors, neuropeptides, and neurotransmitters. Neurotrophic factors and axon guidance molecules, including NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), netrin-1, and EphrinB1 released from cancer cells boost nerve density in tumour tissues by promoting the outgrowth of nerves. These neurons interact with cancer cells and immune cells by secreting neurotransmitters, including noradrenaline, acetylcholine, and CGRP (calcitonin gene-related peptide), from sympathetic, parasympathetic and sensory neurons, respectively. Therefore, in this program, we aim to decipher the impact of neurons on TIME and identify the cross-talk between neurons and cancer/immune cells to identify new therapeutic targets.

Investigating the Impact of TIME on Chemoresistance

Chemoresistance presents a significant challenge in contemporary cancer therapy, frequently resulting in tumour recurrence and metastasis. TIME, which involves cytokines, immune cells, and immunomodulators, is known to influence the treatment response in cancer patients. However, little is known about how changes in the TIME impact tumour growth and therapeutic resistance. Therefore, we aim to understand the intricate relationship between TIME and cancer chemoresistance. In particular, we are interested in how metabolic reprogramming in resistant cells, beyond promoting tumour growth and progression, suppresses T-cell function, influences immune evasion, and compromises immunotherapeutic responses. Therefore, we aim to dissect the molecular, metabolic, and immunological changes in resistant tumours to discover possible targets for boosting anti-tumour immunity and overcoming the chemoresistance challenge, to open a new avenue for more durable and comprehensive anti-cancer therapies.

 

Elucidating the Role of Mycobiome on TIME

Tumour-associated microbiota is the specific microbiome composition in the TME, and it varies in composition from healthy people. Tumour-associated microbiota has been reported in the TIME of different cancers and has been shown to play a role in tumour progression, metastasis and immunosuppression. Metabolite-mediated cross-talk between gut microbiome and cancer/immune cells provides crucial therapeutic targets for colon cancer. Therefore, we aim to investigate the causal relationship and mechanistic pathways to understand the role of microbiota, especially the mycobiome dysbiosis, in cancer patients for developing futuristic therapeutic strategies.

  • Dr. Ruchira Chakrobarty 

    Postdoctoral Fellow

  • Mr. Animesh Kar

    Senior Research Fellow

  • Poonam Yadav

    Senior Research Fellow

  • Kajal Rana

    Junior Research Fellow

  • Dolly Jain

    Senior Research Fellow

  • Varsha Saini

    Senior Research Fellow

  • Somesh K. Jha

    Junior Research Fellow

  • Nishant Pandey

    Junior Research Fellow

  • Bharti Aggarwal

    Junior Research Fellow

  • Shalu

    Junior Research Fellow

  • Devashish Mehta

    ICMR-Senior Research Fellow

Selected Publications

All Publications

Publications from Regional Centre For Biotechnology

  1. Yadav P, Rana K, Nardini V, Khan A, Pani T, Kar A, Jain D, Chakraborty R, Singh R, Jha SK, Mehta D, Sharma H, Sharma RD, Deo SVS, Sengupta S, Patil VS, Faccioli LH, Dasgupta U, Bajaj A.Engineered Nanomicelles inhibit the tumour progression via abrogating the prostaglandin-mediated immunosuppression. J Control Release. 2024 Mar 8:S0168-3659(24)00161-5.
  2. Safwan SM, Kumar N, Mehta D, Singh M, Saini V, Pandey N, Khatol S, Batheja S, Singh J, Walia P, Bajaj A, Xanthone Derivatives can Enhance the Therapeutic Potential of Neomycin against Polymicrobial Gram-negative Bacterial Infections. ACS Infect. Diseas. 2024, 10, 2, 527-540.
  3. Kar A, Dhawan S, Singh A, Bajaj A, Dasgupta U, Insights into Molecular Mechanisms of Chemotherapy Resistance in Cancer Trans. Oncol. 2024, 42, 101901.
  4. Pal G, Ingole KD, Yavvari PS, Verma P, Kumari A, Chauhan C, Chaudhary D, Srivastava S, Bajaj A, Vemanna RS. Exogenous Application of Nanocarrier Double-Stranded RNA Manipulate Physiological Traits and Defense Response against Bacterial Diseases. Mol. Plant Path. 2024, 25, e13417.
  5. Arora A, Singh M, Saini Va, Mehta D, Safwan SM, Pandey N, Verma V, Bajaj A,Cholic Acid-derived Gemini Amphiphile can Eradicate Interkingdom Polymicrobial Biofilms and Wound Infections. ACS Infect. Diseas. 2024, 10, 1, 138-154
  6. Gaur P, Rajendran Y, Srivastava B, Markandey M, Fishbain-Yoskovitz V, Mohapatra G, Suhail, A, Chaudhary S, Tyagi S, Yadav SC, Pandey A.K, Merbl Y, Ahuja V, Srikanth CV. Rab7 dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis. eLife, 2023.
  7. Kar A, Jain D, Kumar S, Rajput K, Pal S, Rana K, Kar R, Jha SK, Medatwal N, Yavvari PS, Mehta D, Pradhan MK, Pandey N, Srivastava A, Mukhopadhyay A, Agarwal U, Sengupta S, Patil VS, Bajaj A, and Dasgupta U.< A Localized Hydrogel-mediated Chemotherapy Causes Immunogenic Cell Death via Activation of Ceramide-mediated Unfolded Protein Response. Sci. Adv. 2023, 9.
  8. Mehta D, Saini V, Bajaj A.Recent Developments in Membrane Targeting Antifungal Agents to Mitigate Antifungal Resistance. RSC Med. Chem. 2023.
  9. Aggarwal B, Saini V, Mehta D, Bajaj A. Dimeric Cholic Acid Peptide Conjugates Act as Effective Antibiotic Adjuvants against Multidrug Resistance (MDR) Gram-Negative Bacterial Infections. Advanced therapeutics. 2023, 6, 2200231.
  10. Kar A, Medatwal N, Rajput K, Mandal S, Pani T, Khan A, Sharma P, Oberoi AS, Vishwakarma G, Deo SV, Jolly MK. Unique Sphingolipid Signature Identifies Luminal and Triple‐Negative Breast Cancer Subtypes. International Journal of Cancer. Int. J. Cancer. 2023, 152, 2410-2423.
  11. Saini V, Mehta D, Gupta S, Kumar S, Rani P, Rana K, Rajput K, Jain D, Pal G, Aggarwal B, Pal S, Gupta SK, Kumar Y, Vemanna RS, Bajaj A.Targeting Vancomycin-Resistant Enterococci (VRE) Infections and Van Operon-Mediated Drug Resistance Using Dimeric Cholic Acid–Peptide Conjugates. J. Med.
  12. Gupta S, Arora A, Saini V, Mehta D, Khan MZ, Mishra DK, Yavvari PS, Singh A, Gupta SK, Srivastava A, Kumar Y, Verma V, Nandicoori VK, Bajaj A. Hydrophobicity of Cholic Acid-Derived Amphiphiles Dictates the Antimicrobial Specificity. ACS Biomater. Sci. Eng. 2022, 8, 4996-5007.
  13. Verma P, Arora A, Rana K, Mehta D, Kar R, Verma V, Srikanth CV, Patil VS, Bajaj A. Gemini Lipid Nanoparticle (GLNP)-mediated Oral Delivery of TNF-α siRNA Mitigates Gut Inflammation via Inhibiting the Differentiation of CD4+ T Cells. Nanoscale, 2022, 14, 14717-14731.
  14. Rajput K, Ansari MN, Jha SK, Pani T, Medatwal N, Chattopadhyay S, Bajaj A, Dasgupta U. Ceramide Kinase (CERK) Emerges as a Common Therapeutic Target for Triple Positive and Triple Negative Breast Cancer Cells. Cancers. 2022, 14, 4496.
  15. Yadav P, Dua C and Bajaj A. Advances in Engineered Biomaterials Targeting Angiogenesis and Cell Proliferation for Cancer Therapy. Chem. Rec. 2022, e202200152.
  16. Chaudhary N, Aggarwal B, Saini V, Yavvari P, Sharma P, Srivastava A, and Bajaj A. Polyaspartate-derived Synthetic Antimicrobial Polymer Enhances Activity of Rifampicin against Multi-drug Resistant Pseudomonas aeruginosa Infections. Biomaterials Sci. 2022, 10, 5158-5171.
  17. Dhingra S, Gaur V, Saini V, Rana K, Bhattacharya J, Loho T, Ray S, Bajaj A, and Saha S. Cytocompatible, Soft and Thick Brush Modified Scaffolds with Prolonged Antibacterial Effect to Mitigate Wound Infections. Biomaterials Sci. 2022, 10, 3856-3877.
  18. Kakkar H, Chaudhary N, Mehta D, Saini V, Maheshwari S, J. Singh J, P. Walia P, and A. Bajaj A. N-methyl Benzimidazole tethered Cholic Acid Amphiphiles can Eradicate S. aureus-mediated Biofilms and Wound Infections. Molecules, 2022, 27, 3501.
  19. Chauhan S, Verma V, Kumar D, Gupta R, Gupta S, Bajaj A, Kumar A, Parshad M. N-heterocycles Hybrids: Synthesis, Antifungal and Antibiofilm Evaluation. Synth. Commun. 2022, 52, 898-911.
  20. 20. Rana K, Pani T, Jha S K, Mehta D, Yadav P, Jain D, Pradhan M K, Mishra S, Kar R, G BR, Srivastava A, U Dasgupta U, Patil V S, and Bajaj A. Hydrogel-mediated Topical Delivery of Steroids can Effectively Alleviate Psoriasis via Attenuating the Autoimmune Responses. Nanoscale 2022, 14, 3834-3848.
  21. Gupta S, Mishra D K, Khan M Z, Saini V, Mehta D, Kumar S, Yadav A, Mitra M, Rani P, Singh M, Nandi C K, Das P, Ahuja V, Nandicoori V K, and Bajaj A. Development of a Highly Specific, Selective, and Sensitive Fluorescent Probe for Detection of Mycobacteria in Human Tissues. Adv. Healthcare Mater. 2022, 11, e2102640.
  22. Pal G, Mehta D, Singh S, Magal K, Gupta G, Jha G, Bajaj A, and Vemanna R. Foliar Application or Seed Priming of Cholic Acid-Glycine Conjugates can Mitigate/Prevent the Rice Bacterial Leaf Blight Disease via Activating Plant Defence Genes. Front. Plant Sci. 2021, 2033.
  23. Kumar S, Pal S, Thakur J, Rani P, Rana K, Kar A, Kar R, Mehta D, Jha S K, Jain D, Rajput K, Srivastava A, Dasgupta U, Patil V S, and Bajaj A. Non-immunogenic Hydrogel-mediated Delivery of Antibiotics Outperforms Clinically used Formulation in Mitigating the Wound Infections. ACS App. Mater. Inter. 2021, 13, 44041–44053.
  24. Mehta D, Saini V, Aggarwal B, Khan A, and Bajaj A. Unlocking the Bacterial Membrane as a Therapeutic Target for Next-generation Antimicrobial Amphiphiles. Mol. Asp. Med. 2021, 81, 100999.
  25. Priya S, Kulshrestha S, Kaur E, Pandit A, Kumar N, Agarwal H, Khan A, Shyam R, Bhagat P, Prabhu JS, Gross I, Freund J, Nagarajan P, Deo SVS, Bajaj A, Mukhopadhyay A and Sengupta S. DNA Damage-dependent CDX2 Inducible microRNA Signature Negatively Regulates Colon Adenocarcinoma by Targeting BRCA1. J. Cell Sci. 2021, 134, jcs258601.
  26. Sreekanth V, Pal S, Kumar S, Komalla V, Yadav P, Shyam VR, Sengupta S, and Bajaj A. Self-assembled Supramolecular Nanomicelles from Bile Acid-Docetaxel Conjugate are Highly Tolerable with Improved Therapeutic Efficacy. Biomater. Sci. 2021, 9, 5626-5639.
  27. Pal S, Soni V, Kumar S, Jha SK, Medatwal N, Rana K, Yadav P, Mehta D, Jain D, Kar R, Srivastava A, V. Patil VS, Dasgupta U, Nandicoori V, and Bajaj A. A Hydrogel-based Implantable Multidrug Antitubercular Formulation Outperforms Oral Delivery. Nanoscale 2021, 13, 13225-13230.
  28. Pani T, Rajput K, Kar A, Sharma H, Basak R, Medatwal N, Saha S, Dev G, Kumar S, Gupta S, Mukhopadhyay A, Malakar D, Maiti TK, Aneeshkumar AG, Deo SVS, Sharma RD, Bajaj A, & Dasgupta U. Alternative Splicing of Ceramide Synthase 2 Alters Levels of Specific Ceramides and Modulates Cancer Cell Proliferation and Migration in Luminal B Breast Cancer Subtype. Cell Death Dis. 2021, 12, 171.
  29. Pal S, Mehta D, Dasgupta U and Bajaj A. Advances in engineering of low molecular weight hydrogels for chemotherapeutic applications. Biomed. Mater. 2021, 16, 024102.
  30. Verma P, Srivastava A, Srikanth C.V, & Bajaj A. Nanoparticle-mediated Gene Therapeutic Strategies for Mitigating the Inflammatory Bowel Disease. Biomater. Sci. 2021, 9, 1481-1502
  31. Sreekanth V, Kar A, Kumar S, Pal S, Yadav P, Sharma Y, Komalla V, Sharma H, Shyam R, Sharma R.D, Mukhopadhyay A0, Sengupta S, Dasgupta U, & Bajaj A. Bile Acid-tethered Docetaxel-based Nanomicelle Mitigates Tumor progression through Epigenetic Changes. Angew. Chem. Int. Ed. 2021, 60, 5394-5399
  32. Gupta R, Thakur J, Pal S, Mishra D, Rani P, Kumar S, Saini S, Singh A, Srivastava A, Prasad R, Gupta S & Bajaj A. Cholic Acid-Derived Amphiphiles can Prevent and Degrade the Fungal Biofilms. ACS Appl. Bio Mater. 2021, 4, 7332-7341.
  33. Medatwal N, Ansari M.N, Kumar S, Pal S, Jha S.K, Verma P, Rana K, Dasgupta U and Baja A. Hydrogel-mediated delivery of celastrol and doxorubicin induces a synergistic effect on tumor regression via upregulation of ceramides. Nanoscale 2020, 12, 18463-18475.
  34. Kumar S. & Bajaj A. Advances in Self-assembled Injectable Hydrogels for Cancer Therapy. Biomater. Sci. 2020, 8, 2055-2073.
  35. Awasthi A, Gupta S, Thakur J, Pal S, Bajaj A and Srivastava A. Polydopamine-on-Liposomes: Stable nanoformulations, Uniform Coatings and Superior Antifouling Performance. Nanoscale 2020, 12, 5021-5030.
  36. Pal S, Medatwal N, Kumar S, Kar A, Komalla V, Yavvari P.S., Mishra D, Rizvi Z.R., Nandan S, Malakar D, Pillai M, Awasthi A, Das P, Sharma R. D., Srivastava A, Sengupta S, Dasgupta U, and Bajaj A. A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism. ACS Central Sci. 2019, 5, 1648-1662.
  37. Gupta S, Thakur J, Pal S, Gupta R, Mishra D, Kumar S, Yadav K, Saini A, Yavvari P, Vedantham M, Singh A, Srivastava A, Prasad R and Bajaj A. Cholic Acid-Peptide Conjugates (CAPs) as Potent Antimicrobials against Interkingdom Polymicrobial Biofilms. Antimicrob. Agents Chemother. 2019, 63, e00520-19.
  38. Kumar S, Thakur J, Yadav K, Mitra M, Pal S, Ray A, Gupta S, Medatwal N, Gupta R, Mishra D, Rani P, Padhi S, Sharma P, Kapil Ar, Srivastava A, Priyakumar, U Deva, Dassgupta U, Thukral L, Bajaj A. Cholic Acid-Derived Amphiphile can Combat Gram-Positive Bacteria-mediated Infections via Disintegration of Lipid Clusters. ACS Biomaterials Sci & Eng. 2019, 5, 4764-4775.
  39. Kidwai S, Bouzeyne R, Chakraborti S, Khare N, Das S, Gosain T, Behura A, Meena C, Dhiman R, Essafi M, Bajaj A, Saini D, Srinivasan N, Mahajan D and Singh R. NU-6027 inhibits growth of Mycobacterium tuberculosis by targeting Protein Kinase D and Protein Kinase G. Antimicrobial Agents Chem. 2019, 63, e00996-19.
  40. Sreekanth V and Bajaj A. Recent Advances in Engineering of Lipid-Drug Conjugates for Cancer Therapy. ACS Biomaterials Sci. & Eng. 2019, 5, 4148-4166.
  41. Sharma Y, Ahmad A, Yavvari PS, Kumar S, Bajaj A, Khan F. Targeted SHP-1 silencing modulates macrophage phenotype leading to metabolic improvement in dietary obese mice. Mol. Ther. Nucleic 2019, 16, 626-636.
  42. Kandanur SGS, Kundu S, Cadena C., Juan HS, Bajaj A, Guzman JD, Nanduri S, Golakoti NR. Design, synthesis, and biological evaluation of new 12-substituted-14-deoxy-andrographolide derivatives as apoptosis inducers. Chemistry Lett. 2019, 73, 1669–1675.
  43. Yavvari PS, Verma P, Mustfa S, Pal S, Kumar S, Awasthi AK, Ahuja V, Srikanth CV, Srivastava A, and Bajaj A. A Nanogel Based Oral Gene Delivery System Targeting SUMOylation Machinery to Combat Gut Inflammation. Nanoscale, 2019,11, 4970-4986.
  44. Srivastava A, Yavvari PS, Awasthi AK, Sharma A, Bajaj A. Emerging Biomedical Applications of Polyaspartic Acid-Derived Biodegradable Polyelectrolytes and Polyelectrolyte Complexes. J. Mater. Chem. 2019, 7, 2102-2122.
  45. Mitra M, Asad M, Kumar S, Yadav K, Chaudhary S, Bhavesh N.S., Khalid S, Thukral L and Bajaj A. Distinct Intramolecular Hydrogen Bonding Dictates Antimicrobial Action of Membrane-Targeting Amphiphiles. J. Phys. Chem. Lett. 2019, 10, 754–760
  46. Yadav K, Kumar S, Mishra S, Asad M, Mitra M, Yavvari PS, Gupta S, Vedantham M, Ranga P, Komalla V, Pal S, Sharma P, Kapil A, Singh A, Singh N, Srivastava A, Thukral L and Bajaj A. Deciphering the Role of Intramolecular Networking in Cholic Acid-Peptide Conjugates (CAPs) at Lipopolysaccharide Surface in Combating Gram-negative Bacterial Infections. J. Med. Chem. 2019, 62, 1875–1886.
  47. Yadav K, Yavvari PS, Pal S, Kumar S, Mishra D, Gupta S, Mitra S, Soni V, Khare N, Sharma P, Srikanth C.V, Kapil A, Singh A, Nandicoori V.K, Bajaj A. Oral Delivery of Cholic Acid-Derived Amphiphile Helps in Combating Salmonella-mediated Gut Infection and Inflammation. Bioconjugate Chem. 2019, 30, 721–732.
  48. Yavvari PS, Pal S, Kumar S, Kar A, Awasthi A,Naaz A, Srivastava A, Bajaj A. An Injectable, Self-healing Chimeric Catechol-Fe(III) Hydrogel for Localized Combination Cancer Therapy. ACS Biomaterials Sci. & Eng. 2017, 3, 3404–3413.
  49. Sreekanth V, Medatwal N, Kumar S, Pal S, Malyla V, Kar A, Bhargava P, Naaz A, Kumar N, Sengupta S, Bajaj A. Tethering of Chemotherapeutic Drug/Imaging Agent to Bile Acid-Phospholipid Increases the Efficacy and Bioavailability with Reduced Hepatotoxicity. Bioconjugate Chem. 2017, 28, 2942–2953.
  50. Kundu S, Bansal S, Muthukumarasamy KM, Sachidanandan C, Motiani R, Bajaj A. Deciphering the Role of Hydrophobic and Hydrophilic Bile Acids in Angiogenesis using in vitro and in vivo Model Systems. Med. Chem. Comm. 2017,8, 2248-2257.
  51. Kidwai S, Park C, Mawatwal S, Tiwari P, Jung MG., Gossain T, Kumar P, Alland D, Kumar S, Bajaj A, Hwang Y, Song CS, Dhiman R, Lee Y, Singh R. The dual mechanism of action of 5-Nitro-1,10-Phenanthroline against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 2017, 61, e00969-17.
  52. Hussain T, Saha D, Purohit G, Kar A, Mukherjee AK , Sharma S, Sengupta S, Dhapola P, Maji B, Vedagopuram S, Horikoshi NT, Horikoshi N, Pandita RK, Bhattacharya S , Bajaj A, Riou JF, TK Pandita, Chowdhury S. Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex. Sci Rep. 2017, 7, 1-13.
  53. Sreekanth V, Medatwal N, Pal S, Kumar S, Sengupta S, Bajaj A. Molecular Self-Assembly of Bile Acid-Phospholipids Controls the Delivery of Doxorubicin and Mice Survivability. Mol. Pharm. 2017, 14,
  54. Yavvari P, Gupta S, Arora D,Nandicoori V, Srivastava A, Bajaj A. Clathrin Independent Killing of Intracellular Mycobacteria and Biofilm Disruptions using Synthetic Antimicrobial Polymers. Biomacromolecules. 2017, 18, 2024–2033
  55. Gupta S, Singh M, Reddy AM, Yavvari PS, Srivastava A, and Bajaj A. Interactions governing the entrapment of anticancer drugs by low molecular weight hydrogelator for drug delivery applications. RSC Adv. 2016, 6, 19751-19757
  56. Kundu S, Kumar S, Bajaj A. Cross-talk between bile acids and gastrointestinal tract for progression and development of cancer and its therapeutic implications. IUBMB Life 2015, 67, 514–523.
  57. S. Kumar, P. Bhargava, V. Sreekanth, and A. Bajaj. Design, Synthesis, and Physico-Chemical Interactions of Bile Acid Derived Dimeric Phospholipid Amphiphiles with Model Membranes. J. Colloid Interface Sci. 2015, 448, 398–406.
  58. Yadav K, Bhargava P, Bansal P, Singh M, Gupta S, Sandhu G, Kumar S, Sreekanth V, and Bajaj A. Nature of the Charged Head Group Dictates the Anticancer Potential of Lithocholic Acid-Tamoxifen Conjugates For Breast Cancer Therapy. Med. Chem. Comm. 2015, 6, 778-787
  59. Sharma A, Bansal S, Pohane A, Bajaj A, Jain V, Srivastava A. Cell-Penetrating Synthetic Antimicrobial Polypeptides (SAMPs) Exhibiting Potent and Selective Killing of Mycobacterium by Targeting its DNA. Chem Eur. 2015, 21, 3540–3545.
  60. M Singh, S Bansal, S Kundu, P Bhargava, A Singh, R Motiani, R Shyam, V Sreekanth, S Sengupta, A Bajaj. Synthesis, Structure-Activity Relationship, and Mechanistic Investigation of Lithocholic Acid Amphiphiles for Colon Cancer Therapy. Med. Chem. Commun. 2015, 6, 192-201

Publication from University of Massachusetts, Amherst, USA.

  1. Rana S, Singla AK, Bajaj A, Elci SG, Miranda OR, Mout R, Yan B, Jirik FR, Rotello VM. (2012) Array-Based Sensing of Metastatic Cells and Tissues Using Nanoparticle-Fluorescent Protein Conjugates. ACS Nano 6:8233.
  2. Rana S, Bajaj A, Mout R, Rotello VM. (2011) Monolayer Coated Gold Nanoparticles for Delivery Applications. Adv Drug Del Rev 64:200.
  3. Saha K, Bajaj A, Duncan B, Rotello VM. (2011) Beauty is Skin Deep: A Surface Monolayer Perspective on Nanoparticle Interactions with Cells and Biomacromolecules. Small 7:1903. 
  4. Biswas J, Bajaj A, Bhattacharya S. (2011) Membranes of Cationic Gemini Lipids based on Cholesterol with Hydroxyl Headgroups and their Interactions with DNA and Phospholipid. J Phys Chem B 115:478.
  5. Subramani C, Saha K, Creran B, Bajaj A, Moyano DF, Wang H, Rotello VM. (2012) Cell Alignment Using Patterned Biocompatible Gold Nanoparticle Templates. Small 8:1209.
  6. Subramani C, Cengiz N, Saha K, Gevrek TN, Yu X, Jeong Y, Bajaj A, Sanyal A, Rotello VM. (2011) Direct Fabrication of Functional and Biofunctional Nanostructures Through Reactive Imprinting. Adv Mater 23:3165.
  7. Subramani C,Bajaj A, Miranda OR, Rotello VM. (2010) Biocompatible Charged and Uncharged Surfaces Using Nanoparticle Films. Adv Mater 22:5420.
  8. Bajaj A, Rana S, Miranda OR, Kim IB, Phillips RL,  Jerry DJ, Bunz UH, Rotello VM. (2010) Cell Surface-based Differentiation of Cell Types and Cancer States Using a Gold Nanoparticle-GFP Based Sensing Array. Chem Sci 1:134.
  9. Bajaj A, Miranda OR, Phillips R, Kim IB, Jerry DJ, Bunz UH, Rotello VM. (2010) Array Based Sensing of Mammalian Cell Types Using Conjugated Polymers. J Am Chem Soc 132:1018.
  10. Bajaj A, Miranda OR, Kim IB, Phillips RL, Jerry DJ, Bunz UH, Rotello VM. (2009) Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays. Proc Nat Acad Sci USA 106:10912.
  11. Bajaj A, Samanta B, Yan HH, Jerry DJ, Rotello VM. (2009) Stability, Toxicity and Differential Cellular Uptake of Protein Passivated-Fe3O4 Nanoparticles. J Mater Chem19:6328.
  12. Krebs MD, Erb RM, Yellen BB, Samanta B, Bajaj A, Rotello VM, Alsberg E. (2009) Formation of Ordered Cellular Structures in Suspension via Label-Free Negative Magnetophoresis. Nano Lett. 9:1812.

Publications from Indian Institute of Science, Bangalore

  1. Bhattacharya S, Bajaj, A. (2009) Recent Advances in Gene Delivery Through Molecular Design of Cationic Lipids. Chem Commun 6432.
  2. Bajaj A, Kondaiah P, Bhattacharya S. (2008) Gene Transfection Efficacies of Novel Cationic Gemini Lipids Possessing Aromatic Backbone and Oxyethylene Spacers. Biomacromolecules 9: 991.
  3. Bajaj A, Mishra S, Kondaiah P, Bhattacharya S. (2008) Effect of the headgroup variation on the gene transfer properties of cholesterol based cationic lipids possessing ether linkage. Biochim Biophys Acta: Biomembr 1778:1222.
  4. Bajaj A, Kondaiah P, Bhattacharya S. (2008) 'Effect of The Nature of Spacer on Gene Transfer Efficacies of Thiocholesterol Derived Gemini Lipids in Different Cell Lines: A Structure-Activity Investigation. J Med Chem 51:2533.
  5. Bajaj A, Paul B, Indi SS, Kondaiah P, Bhattacharya S. (2008) Structure-Activity Investigation on The Gene Transfection Efficiencies of Cariolipin Mimicking Gemini Lipid Analogues. Bioconjugate Chem 19:1283.
  6. Bhattacharya S, Bajaj, A. (2008) Fluorescence and Thermotropic Studies of The Interactions of PEI-Cholesterol Based Lipopolymers With Dipalmitoylphosphatidylcholine (DPPC) Membranes. Biochim Biophys. Acta: Biomembr 1778:2225.
  7. Bajaj A, Kondaiah P, Bhattacharya S. (2008) Synthesis and Gene Transfection Efficacies of PEI−Cholesterol-Based Lipopolymers. Bioconjugate Chem 19:1640.
  8. Bhattacharya S, Bajaj A. (2007) Membrane Forming Properties of Pseudoglyceryl Backbone Based Gemini Lipids Possessing Oxyethylene Spacers. J Phys Chem B 111:2463.
  9. Bajaj A., Kondaiah P, Bhattacharya S. (2007) Synthesis and Gene Transfection Properties of Novel Serum Compatible Cholesterol Based Gemini Lipids Possessing Oxyethylene Spacers. Bioconjugate Chem 18:1537.
  10. Bajaj A, Kondaiah P, Bhattacharya S. (2007) Design, Synthesis and In Vitro Gene Transfection Properties of Novel Cholesterol Based Gemini Lipids and Their Serum Compatibility: A structure-Activity Investigation. J Med Chem 50:2432.
  11. Bhattacharya S, Bajaj A. (2007) Thermotropic and Hydration studies of Gemini Pseudoglyceryl Lipids Possessing Polymethylene Spacers. Langmuir 23:8988.
  12. Bajaj A, Paul B, Indi SS, Kondaiah P, Bhattacharya S. (2007) Effect of the Hydrocarbon Chain Lengths and Spacer Lengths on Gene Transfection Efficacies of Gemini Lipids Based on Aromatic Backbone. Bioconjugate Chem 18:2144.
  13. Bhattacharya S, Bajaj A. (2007) Membrane-Forming Properties of Gemini Lipids Possessing Aromatic Backbone between the Hydrocarbon Chains and the Cationic Headgroup. J Phys Chem B 111:13511.
  14. Paul B, Bajaj A, Indi SS, Bhattacharya S. (2006) Synthesis of Novel Dimeric Lipids Based on an Aromatic Backbone Between the Hydrocarbon Chains and Head Groups. Tetrahedron Lett 47:8401.
  15. Bhattacharya S, Bajaj A. (2005) Recent Trends in Lipid Molecular Design. Curr Opin Chem Biol 9:647.

Former PhD Students

  1. Dr. Priyanka Verma
  2. Dr. Vedagopuram Sreekanth
    Postdoctoral Research Fellow
    Brigham and Women's Hospital
    Harvard Medical School
    Broad Institute of MIT and Harvard
    415, Main St. Cambridge, MA 02142, USA.
    Contact: +1 (857) 999-6505
    Email: vsrikanth19@gmail.com
  3. Dr. Somanath Kundu
    State University of New York
    Upstate Medical University
    Department of Neurosci & Physiology
    505 Irving Ave, Rm 3709
    Syracuse, NY 13210.
    Email: somnathkundu09@gmail.com
  4. Dr. Kavita Yadav
    Email: yadav86kavita@gmail.com
  5. Dr. Sandeep Kumar
    Postdoctoral Research Fellow
    Translational Tissue Engineering Center
    Wilmer Eye Institute and Department of Biomedical Engineering
    Johns Hopkins University School of Medicine
    Baltimore, MD 21205, USA
  6. Nihal Medatwal
    Joining soon at
    Dept. of Systems Pharmacology and Translational Therapeutics
    University of Pennsylvania
    Philadelphia, PA, USA
  7. Sanjay Pal
    Joining soon at
    Cancer Biomaterials Engineering Section
    Laboratory of Cancer Immunometabolism
    National Cancer Institute, USA

  8. Former Postdoctoral Fellows

  9. Dr. Siddhi Gupta
     
  10. Dr. Manish Singh
    Postdoctoral Research Fellow
    Nagoya Institute of Technology
    Showa-ku
    Nagoya 466-8555, Japan
    Email: maneeshsingh23@gmail.com
  11. Dr. Sandhya Bansal
    Postdoctoral Research Fellow
    Norton Thoracic Institute
    St. Joseph's Hospital and Medical Center
    Dignity Health
    Phoenix-85013, Arizona, USA
    Contact: +16504459169
    Email: sandhyabansal@gmail.com
  12. Dr. Rachana Trivedi
    Postdoctoral Research Fellow
    Geriatrics Department
    University of North Dakota
    Grand Forks, North Dakota-58201, USA
    Contact: +17017398832
    Email: rachana.cdri@gmail.com
  13. Dr. Rajender K Motiani
    Assistant Professor and Principal Investigator
    Laboratory of Calciomics and Systemic Pathophysiology (LCSP)
    Regional Centre for Biotechnology
    NCR Biotech Science Cluster
    Faridabad-121001, India
    Contact: +91-9717427369
    Email: rajender.motiani@rcb.res.in

  14. Former Research Fellows

  15. Varsha Komalla
    PhD Candidate
    Graduate School of Health
    University of Technology Sydney
    67 Thomas Street, Ultimo
    NSW, Sydney, Australia-2007
    Email: varshakomalla56@gmail.com
  16. Vamshikrishna Malyla
    PhD Student
    Centre for Inflammation
    Centenary Institute
    Building 93, Royal Prince Alfred Hospital
    Missenden Rd (follow Johns Hopkins Drive)
    Camperdown, NSW 2050, Australia
    Contact: +61 434 978 439
    Email: vamshi.mk92@gmail.com, v.malyla@centenary.org.au
  17. Mohammad Asad
    Project Assistant
    CSIR-Institute of Genomics and Integrative Biology, New Delhi
    Computational Structural Biology
    Contact: +91 7800 915 616
    Email: asadpharma786@gmail.com
  18. Priyanshu Bhargava
    Researcher & Doctoral Candidate
    Biomedical Research Institute
    National Institute of Advanced Industrial Science & Technology (AIST)
    Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki - 305 8562, Japan
    Email: bhargava.priyanshu@aist.go.jp

  19. Former Trainees

  20. Sayan Dutta
    Graduate Student
    Department of Medicinal Chemistry and Molecular Pharmacology
    Purdue Institute of Interdisciplinary Neuroscience
    Purdue University
    West Lafayette
    Indiana-47906, USA
    Email: sayanm06@gmail.com
    Phone: +1 2174187206
  21. Omkar Kulkarni
    PhD Student
    Department of Biological Sciences
    National University of Singapore (NUS), Singapore
    Email: omkar21@gmail.com
  22. V. Madhukar
    PhD Student
    Institute of Biomedicine
    Research Centre for Cancer, Infections and Immunity
    University of Turku
    Kiinamyllynkatu 10
    FI-20520 TURKU, Finland
    E-mail ID: madhukar.vedantham@utu.fi
    Phone no.: +358-402521503
  • P. Boomathi Pandeswari
    CSIR-SRF
    Advanced Centre for Bio-separation Technology (CBST)
    Vellore Institute of Technology (VIT)
    Vellore-632014, Tamil Nadu, India
    E-mail ID: boomathi.91@gmail.com
    Ph: +91-9566502605
  • Prithvi
    B.Tech
    Working on Halophilic Fungi
    PSG Groups
    Coimbatore
    Email: prithvitamil08@gmail.com
Dr. Avinash Bajaj
Professor

Regional Centre for Biotechnology
NCR Biotech Science Cluster
3rd Milestone, Faridabad-Gurgaon Expressway
P.O. Box No. 3, Faridabad - 121 001
Haryana (NCR Delhi), India
E-mail: bajaj[at]rcb[dot]res[dot]in
Phone: 91 129 2848831

no text bajaj[at]rcb[dot]res[dot]in
no text 91 129 2848831

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