
Senior Research Fellow
Investigating Signaling Pathways of Thrombosis, Inflammation and Immune Response in Human Diseases including Viral Infections and Polymorphism Associated Pathogenesis.
Viral Infections and host immune response:Dengue virus (DENV), Japanese encephalitis virus (JEV), Chikungunya virus (CHIKV), SARS-CoV-2, Human papillomavirus (HPV), Monkey pox virus (MPOXV).
Investigating viral pathogenesis and host immune response using in-vitro experiments, mice models as well as patients’ samples. Severity of viral pathogenesis in diabetes and polymorphism associated disorders. Identifying biomarkers and molecular targets. Designing small molecule anti-viral and vaccine.
Related pub: DENV~ Gaur K et al. 2024 EMBO Molecular Medicine, JEV/DENV~ Singh A et al. 2023 Journal of Thrombosis and Haemostasis; Singh A et al. 2023 Cytokine; Ojha et al. 2019 EBioMedicine. SARS-CoV-2~ Joshi G et al. 2025 Clinical and Translation Medicine, Agarwal S et al. 2022. Clinical and Translation Medicine; Shrimali NM et al. 2021 EBioMedicine; Agarwal S et al. 2023 FEBS Journal; Agarwal S et al. 2023 Clinical and Experimental Immunology.
Genetic polymorphisms and associated phenotypes:Tibetan mutation (PHD2D4E;C127S); Mappila mutation (FBLN4D203A); Kashmiri polymorphism. Investigating the high-altitude adaptation associated PHD2D4E;C127S mutation in Tibetans. Investigating role of Lethal Aortopathy syndrome associated with FBLN4D203A mutation among Mappila children of Malabar, Kerala, India.Kashmiri Thrombocytopenia; about 20% of Healthy Individuals from Kashmir Valley have lower platelet counts (<90). We are investigating if any genetic polymorphisms are associated with it.
Related pub: PHD2D4E;C127S polymorphisms~ Ghosh R et al. 2025 PLOS Pathogens, Shrimali NM et al. 2025 Thrombosis and Haemostasis, Bhattacharya S et al. 2021 EBioMedicine, Shrimali NM et al. 2021 EBioMedicine.
Hemolytic disorders and thrombo-inflammation:Investigating the pathogenesis of systemic inflammation in hemolytic disorders including paroxysmal nocturnal hemoglobinuria (PNH) and sickle cell disease (SCD): Role of extracellular hemoglobin.
Related pub: Singhal R et al. 2015 Haematologica; Singhal R et al. 2016 Clinical Immunology, Singhal R et al. 2018 Euro J Immunology, Singhal R et al. 2019 Journal Immunology Research, Bhasym A et al. 2019 Clinical and Experimental Immunology.
Autoimmune disorders and thrombo-inflammation:Investigating the systemic inflammation in autoimmune disorders like atypical hemolytic uremic syndrome (aHUS) and systemic lupus erythematosus (SLE): Role of complement factors H polymorphisms.
Related pub: aHUS~ Bhasym A et al. 2019 Journal of Clinical Immunology
Review Articles
Book Chapters
Regional Centre for Biotechnology
NCR Biotech Science Cluster
3rd Milestone, Faridabad-Gurgaon Expressway
P.O. Box No. 3, Faridabad - 121 001
Haryana (NCR Delhi), India
E-mail: prasenjit at rcb dot res dot in
Phone: 91 129-2848821