
Senior Research Fellow
Investigating Signaling Pathways of Thrombosis, Inflammation and Immune Responses in Human Diseases including Viral Infections and Polymorphism Associated Pathogenesis.
Viral Infections and host immune response: Dengue virus (DENV), Japanese encephalitis virus (JEV), Chikungunya virus (CHIKV), SARS-CoV-2, Human papillomavirus (HPV), Monkey pox virus (MPOXV).
Investigating viral pathogenesis and host immune responses using in-vitro experiments, mice models and patients’ samples. Severity of viral pathogenesis in disease conditions like Diabetes and Polymorphism Associated Disorders. Identifying biomarkers and molecular targets. Designing small molecule therapeutics and vaccines.
Related pub: DENV~ Gaur K et al. 2024 EMBO Molecular Medicine, JEV/DENV~ Singh A et al. 2023 Journal of Thrombosis and Haemostasis; Singh A et al. 2023 Cytokine; Ojha et al. 2019 EBioMedicine. SARS-CoV-2~ Joshi G et al. 2025 Clinical and Translation Medicine, Agarwal S et al. 2022. Clinical and Translation Medicine; Shrimali NM et al. 2021 EBioMedicine; Agarwal S et al. 2023 FEBS Journal; Agarwal S et al. 2023 Clinical and Experimental Immunology.
Genetic polymorphisms and associated phenotypes: Tibetan mutation (PHD2D4E;C127S); Mappila mutation (FBLN4D203A); Kashmiri polymorphism.
Investigating the high-altitude adaptation associated PHD2D4E;C127S mutation in Tibetans.
Investigating role of Lethal Aortopathy syndrome associated with FBLN4D203A mutation among Mappila children of Malabar, Kerala, India.
Kashmiri Thrombocytopenia; about 20% of Healthy Individuals from Kashmir Valley have lower platelet counts (<90). We are investigating if any genetic polymorphisms are associated with it.
Related pub: PHD2D4E;C127S polymorphisms~ Shrimali NM et al. 2025 Thrombosis and Haemostasis, Bhattacharya S et al. 2021 EBioMedicine; Shrimali NM et al. 2021 EBioMedicine.
Hemolytic disorders and thrombo-inflammation:
Investigating the pathogenesis of systemic inflammation in hemolytic disorders including paroxysmal nocturnal hemoglobinuria (PNH) and sickle cell disease (SCD): Role of extracellular hemoglobin.
Related pub: Singhal R et al. 2015 Haematologica; Singhal R et al. 2016 Clinical Immunology; Singhal R et al. 2018 Euro J Immunology; Singhal R et al. 2019 Journal Immunology Research; Bhasym A et al. 2019 Clinical Experimental Immunology.
Autoimmune disorders and thrombo-inflammation:
Investigating the systemic inflammation in autoimmune disorders like atypical hemolytic uremic syndrome (aHUS) and systemic lupus erythematosus (SLE): Role of complement factors H polymorphisms.
Related pub: aHUS~ Bhasym A et al. 2019 Journal of Clinical Immunology
Review Articles
Book Chapters
Regional Centre for Biotechnology
NCR Biotech Science Cluster
3rd Milestone, Faridabad-Gurgaon Expressway
P.O. Box No. 3, Faridabad - 121 001
Haryana (NCR Delhi), India
E-mail: prasenjit at rcb dot res dot in
Phone: 91 129-2848821