Centrosome is a membrane-less self-replicating, microtubule based organelle, that is established as the major organizer (MTOC) in animal cell. However, its role is not fully understood beyond spindle assembly and cell division

. Often centriole associated structures like centrosome, centriolar satellite and ciliary basal bodies are dynamic interconvertible membrane-less structures regulated by certain common signaling pathways operating at various spatio-temporal windows across mitotic and extra-mitotic phases. 

Today we realize more robust functioning of these organelles in regulating events beyond cell division like subcellular trafficking, intracellular signaling, polarity establishment, development and differentiation. 

On the contrary these structures are totally dispensable in certain terminally differentiated states and other unique and interesting instances. Again the process of centrosomal inactivation is poorly defined and still remains an open end for research.

With the advent of imaging and proteomic tools, we have started gaining better insights off late in terms of the structure, composition and functioning of centrosomes for some but not all cellular cues across the physiological and pathological states. 

Our research interests lie in understanding the perturbation of centriole based organelles across varying disease state that contributes to the pathobiological and explore the intervention strategies. 

We majorly try understanding the centrosome and ciliary structures using imaging based approaches and the signaling aspects of these organelles by means of basic biochemical and molecular cell biology approaches combining the tools of modern proteomics, electron microscopy and super-resolution imaging. Laboratory of Centrosome and Cilia is broadly interested in studying,

• Centriolar organelle in establishing and manifesting viral infection pathology.
• Centriolar and ciliary signallosomes across infection and ageing disorders.
• Phase separation of centrosome targeted proteins.
• Contribution of centrosomes in neurodegenerative diseases.
• Centriolar components participating in DNA damage response.
• Centrosomes as a druggable target.