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Dr. Prasenjit Guchhait
Professor
  • PhD, Banaras Hindu University
  • Postdoc at Baylor College of Medicine, USA
  • Instructor at Baylor College of Medicine, USA
  • Assistant Professor at Baylor College of Medicine, USA
  • Associate Professor at Regional Centre for Biotechnology, India
prasenjit[at]rcb[dot]res[dot]in

Investigating Signaling Pathways of Thrombosis, Inflammation and Cytokine/Antibody Responses in Viral Infections and Polymorphism Associated Pathogenesis.

Viral Infections: Dengue virus (DENV), Japanese encephalitis virus (JEV), Chikungunya virus (CHIKV), SARS-CoV-2, Human papillomavirus (HPV), Monkey pox virus (MPOXV).
Investigating viral pathogenesis using in-vitro experiment, mice models and patients’ samples. Severity of Viral infections in Diabetes. Identifying biomarkers and molecular targets. Designing small molecule therapeutics and vaccines.
Related pub: Gaur K et al. 2024 EMBO Molecular Medicine, Singh A et al. 2023 Journal of Thrombosis and Haemostasis; Singh A et al. 2023 Cytokine; Ojha et al. 2019 EBioMedicine. Agarwal S et al. 2022. Clinical and Translation Medicine; Shrimali NM et al. 2021 EBioMedicine; Agarwal S et al. 2023 FEBS Journal; Agarwal S et al. 2023 Clinical and Experimental Immunology.

Genetic polymorphism: Tibetan mutation (PHD2D4E;C127S); Mappila mutation (FBLN4D203A); Kashmiri polymorphism. 
Investigating the high-altitude adaptation associated PHD2D4E;C127S mutation in Tibetans. 
Investigating role of Lethal Aortopathy syndrome associated with FBLN4D203A mutation among Mappila children of Malabar, Kerala, India.
Kashmiri Thrombocytopenia; about 20% of Healthy Individuals from Kashmir Valley have lower platelet counts (<90). We are investigating if any genetic polymorphisms are associated with it.
Related pub: Bhattacharya S et al. 2021 EBioMedicine; Shrimali NM et al. 2021 EBioMedicine.

Hemolytic disorders
Investigating the pathogenesis of systemic inflammation in hemolytic disorders including paroxysmal nocturnal hemoglobinuria (PNH) and sickle cell disease (SCD): Role of extracellular hemoglogin (Hb).
Related pub: Sighal R et al. 2015 Haematologica; Sighal R et al. 2016 Clinical Immunology; Sighal R et al. 2018 Euro J Immunology; Sighal R et al. 2019 Journal Immunology Research; Bhasym A et al. 2019 Clinical Experimental Immunology.

Autoimmune disorders
Investigating the systemic inflammation in autoimmune disorders like atypical hemolytic uremic syndrome (aHUS) and systemic lupus erythematosus (SLE): Role of complement factors H polymorphisms. 
Related pub: Bhasym A et al. 2019 Journal of Clinical Immunology

  • Gunjit Setia

    Junior Research Fellow-Project

  • Deeksha Verma

    Junior Research Fellow

  • Aarti Muralitharan

    Junior Research Fellow-Project

  • Richa Kumari

    Junior Research Fellow-Project

  • Gulistan Parveen

    Junior Research Fellow-Project

  • Navya Chauhan

    Junior Research Fellow-Project

  • Riya Ghosh

    Junior Research Fellow-Project

  • Sakshi Mandal

    Junior Research Fellow

  • Anupam Chawla

    Junior Research Fellow

  • Md. Sahil

    Junior Research Fellow

  • Shalu Singh

    Junior Research Fellow

  • Tejeswara Rao Asuru

    Junior Research Fellow

  • Garima Verma

    Senior Research Fellow

  • Garima Joshi

    Senior Research Fellow

  • Kishan K Gaur

    Senior Research Fellow

  • Guchhait Prasenjit and Asthana Shailendra (June’ 2023) anti-viral small molecule against dengue. Reference number 202011005513. Jointly, Regional Centre for Biotechnology (RCB), Faridabad, India, and Translational Health Science Technology Institute (THSTI), Faridabad, India.
     

Selected Publications

  1. Gaur KK, Asuru TR, Srivastava M, Singh N, Purushotham N, Poojary B, Das B, Bhattacharyya S, Asthana S, Guchhait P (2024) 7D, a small molecule inhibits dengue infection by increasing interferons and neutralizing-antibodies via CXCL4:CXCR3:p38:IRF3 and Sirt1:STAT3 axes respectively. EMBO Molecular Medicine https://doi.org/10.1038/s44321-024-00137-8
  2. Singh A, Ghosh R, Asuru TR, Prajapat S, Joshi G, Gaur KK, Shrimali NM, Ojha A, Vikram NK, Poncz M, Kalia M, Guchhait P (2023) Inhibition of platelet factor 4:CXCR3 pathway prevents JEV and DENV infection. Journal of Thrombosis and Haemostasis, doi.org/10.1016/j.jtha.2023.11.015.
  3. Agarwal S, Kaur S, Asuru TR, Joshi G, Shrimali NM, Singh A, Singh ON, Srivastva P, Shrivastava T, Vrati S, Surjit M, Guchhait P (2022) Dietary αKG inhibits SARS CoV-2 infection and rescues inflamed lungs to restore normal O2 saturation by inhibiting pAkt. Clinical and Translational Medicine e1041,12(9):1-6.
  4. Shrimali NM, Agarwal S, Kaur S, Bhattacharya S, Bhattacharyya S, Prchal JT, Guchhait P (2021) KG inhibits thrombosis and inflammation by prolyl hydroxylase-2 mediated inactivation of phospho-Akt. EBioMedicine 73:103672.
  5. Bhattacharya S, Shrimali NM, Mohammad G, Koul PA, Prchal JT and Guchhait P. (2021) Gain-of-function Tibetan PHD2D4E;C127S variant suppresses monocyte function: a lesson in inflammatory response to inspired hypoxia. EBioMedicine 68:103418.
  6. Ojha A, Bhasym A, Mukherjee S, Annarapu GK, Bhakuni T, Akbar I, Seth T, Vikram NK, Vrati S, Basu A, Bhattacharyya S, Guchhait P (2019) Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses. EBioMedicine, 39: 332-347
  7. Bhasym A, Gurjar BS, Sriharsha TM, Prabhu S, Puraswani M, Khandelwal P, Saini H, Saini S, Verma AK, Chatterjee P, Bal V, George A, Sharma A, Hari P, Sinha A, Bagga A, Rath S, Guchhait P (2019) Altered Peripheral Blood Leucocyte Phenotype and Responses in Healthy Individuals with Homozygous Deletion of FHR1 and FHR3 Gene. Journal of Clinical Immunology, doi.org/10.1007/s10875-019-00619-2
  8. Singhal R, Annarapu GK, Pandey A, Chawla S, Ojha A, Gupta A, Cruz MA, Seth T, Guchhait P (2015) Hemoglobin interaction with GP1b-alpha induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis. Haematologica 100(12): 1526-33.

All Publications

  1. Asuru TR, Rajagopal RE, Rejendran A, Parveen G, Das A, Devi P, Dasgupta S, Kalyanaraman, Guchhait P*, Thiagarajan P*. (2024) Identification of Cobra and Viper bites in Southern India using ELISA. Laboratory Medicine (In press)
  2. Gaur KK, Asuru TR, Srivastava M, Singh N, Purushotham N, Poojary B, Das B, Bhattacharyya S, Asthana S, Guchhait P* (2024) 7D, a small molecule inhibits dengue infection by increasing interferons and neutralizing-antibodies via CXCL4:CXCR3:p38:IRF3 and Sirt1:STAT3 axes respectively. EMBO Molecular Medicine https://doi.org/10.1038/s44321-024-00137-8. 
  3. Singh A, Ghosh R, Asuru TR, Prajapat S, Joshi G, Gaur KK, Shrimali NM, Ojha A, Vikram NK, Poncz M, Kalia M, Guchhait P* (2023) Inhibition of platelet factor 4:CXCR3 pathway prevents JEV and DENV infection. Journal of Thrombosis and Haemostasis, 22:3:818-833 doi.org/10.1016/j.jtha.2023.11.015.
  4. Agarwal S, Saha S, Ghosh R, Sarmadhikari S, Asthana S, Maiti TK, Khadgawat R, Guchhait P* (2023) Elevated glycosylation of CD36 in platelets is a risk factor for oxLDL mediated platelet activation in type 2 diabetes. FEBS Journal, https://doi.org/10.1111/febs.16976
  5. Singh A, Ghosh R, Guchhait P* (2023) CXCR3 antagonist rescues ER stress and reduces inflammation and JEV infection in mice brain. Cytokine, 7:172:156380. 10.1016/j.cyto.2023.156380
  6. Agarwal S, Ghosh R, Verma G, Khadgawat R, Guchhait P* (2023) Alpha-ketoglutarate supplementation reduces inflammation and thrombosis in type 2 diabetes by suppressing leukocytes and platelet activation. Clinical and Experimental Immunology, https://doi.org/10.1093/cei/uxad086.
  7. Kumari Sharda, Bandyopadhyay Bhaswati, Singh Anamika, Aggarwal Suruchi, Yadav Amit, Vikram Naval, Guchhait Prasenjit and Banerjee Arup (2023) Extracellular vesicles recovered from plasma of severe dengue patients induced CD4+T cell suppression through PD-L1/PD1 interaction. mBIO (accepted). 
  8. Gupta A, Sood A, Bhardwaj D, Shrimali N, Singhmar R, Chaturvedi S, Guchhait P, Agrawal G* (2023) Functionalized Chitosan Decorated Hafnium Oxide@Gold Core-Shell Nanoparticles for Multimodal Cancer Therapy. Advanced Therapeutics (accepted).
  9. Agarwal S, Kaur S, Asuru TR, Joshi G, Shrimali NM, Singh A, Singh ON, Srivastva P, Shrivastava T, Vrati S, Surjit M, Guchhait P* (2022) Dietary αKG inhibits SARS CoV-2 infection and rescues inflamed lungs to restore normal O2 saturation by inhibiting pAkt. Clinical and Translational Medicine e1041,12(9):1-6.
  10. Gupta A, Sood A, Dhiman A, Shrimali N, Singhmar R, Guchhait P, Agarwal G*. (2022) Redox Responsive Poly(allylamine)/Eudragit S-100 Nanoparticles for Dual Drug Delivery in Colorectal Cancer. Biomaterials Advances 143:e213184.
  11. Thakur SK, Ghosh R, Gaur KK, Guchhait P, Eswaran SV* (2022) Anti-cancer activity of water-soluble reduced Graphene oxide-aryl arizidino manganese II complex. J Biomedical Nanotechnology 18:1-8.
  12. Mohanbhai SJ, Sardoiwala MN, Gupta S, Shrimali NM, Roy Choudhury S, Sharma SS, Guchhait P, Karmakar S* (2022) Colon targeted chitosan-melatonin nanotherapy for preclinical inflammatory bowel disease. Biomaterials advances 136:e212796.
  13. Gautam D, Kailashiya J, Tiwari A, Chaurasia RN, Annarapu GK, Guchhait P, Dash D* (2022) Fibrinogen mitigates prion-mediated platelet activation and neuronal cell toxicity. Frontiers Cell and developmental Biology, 10:e834016.
  14. Kaur S, Singh A, Kaur J, Verma N, Pandey AK, Das S, Bhattacharyya S, Guchhait P* (2022) Upregulation of cytokine signaling in platelet increases risk of thrombophilia in severe COVID-19 patients. Blood Cells Molecules and Diseases, 94:102653. 
  15. Chaudhury N, Srivastava S, Dave U, Ojha A, Guchhait P, Chandele A, Patel AK*. (2022). High-mobility group box 1 protein promotes dengue virus replication by interacting with untranslated regions of viral genome. Virus Research, 309:198668.
  16. Shrimali NM, Agarwal S, Kaur S, Bhattacharya S, Bhattacharyya S, Prchal JT, Guchhait P* (2021) KG inhibits thrombosis and inflammation by prolyl hydroxylase-2 mediated inactivation of phospho-Akt. EBioMedicine 73:103672.
  17. Bhattacharya S, Shrimali NM, Mohammad G, Koul PA, Prchal JT and Guchhait P*. (2021) Gain-of-function Tibetan PHD2D4E;C127S variant suppresses monocyte function: a lesson in inflammatory response to inspired hypoxia. EBioMedicine 68:103418.
  18. Srivastava S, Chaudhary N, Ojha A, Guchhait P, Patel AK*. (2021) Signal transducer and activator of transcription 3 (STAT3) acts as a proviral factor for dengue virus propagation. Virus Research 300:198436.
  19. Thakur S, Saha S, Guchhait P, Eswaran S*. (2020) Fullarazirman, nano water-soluble Fullerene C60-Mn (II) Triadduct complex with anti-cancer activity comparable to Doxorubicin. J Biomedical Nanotechnology. 16:481-491.
  20. Thakur S, Goswami K, Rao P, Kaushik S, Singh B, Sharma PK, Asthana S, Bhattacharjee S, Guchhait P, Eswaran S*. (2020) A Fluoresceinated Aminohexanol Tethered Inositol Hexakisphosphate: Studies on Arabidopsis thaliana, Drosophila melanogaster and Docking with 2P1M Receptor. ACS Omega, 0c00961. 
  21. Sardoiwala N M, Kushwaha A, Dev A, Nishith S, Guchhait P, Karmakar S, Roy Choudhury S*. (2020) Hypericin loaded transferrin nanoparticles induce PP2A regulated BMI1 degradation in colorectal cancer specific chemo-Photodynamic Therapy. ACS Biomaterials Science & Engineering, 6,5, 3139-3153.
  22. Sood A, Dev A, Mohanbhai SJ, Shrimali N, Kapasiya M, Kushwaha A, Choudhury SR, Guchhait P, Karmakar S* (2019) Development and targeting efficacy of disulfide bridged chitosan-Eudragit S-100 nanoparticles for colorectal cancer, ACS Applied Nano Materials. 2, 10: 6409-17.
  23. Thakur S, Goswami K, Bhattacharjee S, Soni U, Guchhait P, Eswaran S*. (2019) A Water Soluble Single Walled Carbon Nanotube Aryl Aziridino Carboxylic Acid Decorated Mn (II) Complex Increased Root Growth in Arabidopsis thaliana. Chemistry Select. 201904205.
  24. Bhasym A, Bhakuni T and Guchhait P* (2019) Elevated surface-bound complement factor-H alters the function of platelets and monocytes in FHR1/3-null healthy individuals. Blood Cells Molecules Diseases, 79:102349.
  25. Bhasym A, Annarapu GK, Saha S, Shrimali NM, Gupta S, Seth T, Guchhait P*. (2019) Neutrophils develop rapid proinflammatory response after engulfing Hb-activated platelets under intravascular hemolysis. Clinical and Experimental Immunology, doi: 10.1111/cei.13310
  26. Bhakuni T, Singhal R, Aannarapu GK, Sharma A, Mahapatra M, Saxena R, Guchhait P* (2019) Unique case of autoantibody mediated inactivation of ADAMTS13 in an Indian TTP patient. Blood Cells Molecules Diseases, 77:29-33
  27. Bhasym A, Gurjar BS, Sriharsha TM, Prabhu S, Puraswani M, Khandelwal P, Saini H, Saini S, Verma AK, Chatterjee P, Bal V, George A, Sharma A, Hari P, Sinha A, Bagga A, Rath S, Guchhait P* (2019) Altered Peripheral Blood Leucocyte Phenotype and Responses in Healthy Individuals with Homozygous Deletion of FHR1 and FHR3 Gene. Journal of Clinical Immunology, doi.org/10.1007/s10875-019-00619-2
  28. R Singhal, DK Rathore, T Bhakuni, T Seth, P Guchhait* (2019) Absence of Non-classical Monocytes in Hemolytic Patients: Free Hb and NO-Mediated Mechanism. Journal of Immunology Research, doi.org/10.1155/2019/1409383
  29. Ojha A, Bhasym A, Mukherjee S, Annarapu GK, Bhakuni T, Akbar I, Seth T, Vikram NK, Vrati S, Basu A, Bhattacharyya S, Guchhait P* (2019) Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses. EBioMedicine, 39: 332-347
  30. Singhal R, Chawla S, Batra H, Gupta S, Ojha A, Rathore DK, Seth T and Guchhait P*. (2018) Engulfment of Hb-activated platelets differentiates monocytes into pro-inflammatory macrophages in PNH patients. European J Immunology. 48(8):1285-1294 doi: 10.1002/eji.201747449.
  31. Gurjar BS, Sriharsha TM, Bhasym A, Prabhu S, Puraswani M, Khandelwal P, Saini H, Saini S, Verma AK, Chatterjee P, Guchhait P, Bal V, George A, Rath S, Sahu A, Sharma A, Hari P, Sinha A, Bagga A. (2018) Characterization of genetic predisposition and autoantibody profile in atypical hemolytic uremic syndrome. Immunology. 154, 663-672. doi: 10.1111/imm.12916.
  32. Ojha A, Nandi D, Batra H, Singhal R, Annarapu GK, Bhattacharyya S, Seth T, Dar L, Medigeshi GR, Vrati S, Vikram NK, Guchhait P*. (2017) Platelet activation determines the severity of thrombocytopenia in dengue infection. Scientific Reports, 7:41697. 
  33. Tashi T, Reading NS, Moore LG, Wuren T, Hu H, Teng F, Shestakova A, Lorenzo F, Burjanivova T, Koul P, Guchhait P, Wittwer C, Julian CG, Shah B, Huff CD, Ge R, Gordeuk VR, Prchal JT*. (2017) Gain-of-Function EGLN1 Prolyl Hydroxylase (PHD2 D4E:C127S) in Combination with EPAS1 (HIF2α) Polymorphism Lowers Hemoglobin Concentration in Tibetans. Journal of Molecular Medicine, p1-6. 
  34. Singhal R, Chawla S, Rathore D, Bhasym A, Annarapu GK, Sharma V, Seth T, Guchhait P*. (2016) Development of pro-inflammatory phenotype in monocytes after engulfing Hb-activated platelets in hemolytic disorders. Clinical Immunology, doi:10.1016/ j.clim.2016.12.007. 
  35. Annarapu GK, Singhal R, Gupta A, Chawla S, Batra H, Seth T, and Guchhait P*. (2016) HbS binding to GP1bα activates platelets in sickle cell disease. PLoS One, 11(12): e0167899. doi:10.1371/journal. 
  36. Annarapu GK, Singhal R, Peng Y, Guchhait P*. (2016) Inhibition of Hb binding to GP1bα abrogates Hb-mediated thrombus formation on immobilized VWF and collagen under physiological shear stress. PLoS One, 11(4):e0154276. 
  37. Singhal R, Annarapu GK, Pandey A, Chawla S, Ojha A, Gupta A, Cruz MA, Seth T, Guchhait P*. (2015) Hemoglobin interaction with GP1balpha induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis. Haematologica 100(12): 1526-33. 
  38. Da Q, Teruya M, Guchhait P, Teruya J, Olson JS, Cruz MA*. (2015) Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications on circulatory devices. Blood. 126(20):2338-41. 
  39. Lorenzo LR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuran T, Li GR, McClain DL, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin Jr WG, Koivunen P & Prchal JT*. (2014) A genetic mechanism for Tibetan high-altitude adaptation. Nature Genetics, 46:951-956. 
  40. Zhou Z, Thiagarajan P, Udden MA, Lopez JA, Guchhait P*. (2011) Membrane sulfatide plays a crucial role in the sickle erythrocytes adhesion to matrix and endothelial ligands. Thrombosis Haemostasis. 105:1046-52. 
  41. Zhou Z, Han H, Cruz MA, Jose JA, Dong JF, Guchhait P*. (2009) Hemoglobin blocks von Willebrand factor proteolysis by ADAMTS-13: a mechanism associated with sickle cell disease. Thrombosis Haemostasis, 101 (6): 1070-77. 
  42. Guchhait P*, Shrimpton C, Honke K, Rumbaut R, Lopez JA, Thiagarajan P. (2008) Effects of an anti-sulfatide single-chain antibody probe on platelet function. Thrombosis Haemostasis, 99(3):552-57. 
  43. Dasgupta SK, Abdel-Monem H, Guchhait P, Nagata S, Thiagarajan P*. (2008) Role of lactadherin in the clearance of phosphatidylserine-expressing red blood cell in sickle cell disease. Transfusion, 48(11):2370-76.
  44. Guchhait P, Dasgupta SK, Le A, Yellapragada S, Lopez JA, Thiagarajan P*. (2007) Lactadherin mediates sickle cell adhesion to the vascular endothelial cells in flowing blood. Hematologica, 92(9):1266-67.  
  45. Dasgupta SK, Guchhait P, Thiagarajan P*. (2006) Lactadherin binding and phosphatidylserine expression on cell surface-comparison with annexin A5. Translational Research, 148:19-25. 
  46. Lasser G, Guchhait P, Ellsworth J, Bishop P, Cruz MA, Lopez JA, Fruebis J*. (2006) C1q-TNF related protein-1 (CTRP-1), a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen. Blood, 107:423-430. 
  47. Guchhait P, Lopez JA, Thiagarajan P*. (2004) Characterization of autoantibodies against sulfatide from a V-gene phage-display library derived from patients with systemic lupus erythematosus. J. Immunol. Methods, 295: 129–137. 
  48. Bernardo A, Bergeron AL, Sun CW, Guchhait P, Cruz MA, Lopez JA, Dong JF*. (2004) Von Willebrand factor present in fibrillar collagen enhances platelet adhesion to collagen and collagen-induced platelet aggregation. J. Thromb. Haemost. 2(4): 660-9. 
  49. Guchhait P, Tosi MF, Smith CW, Chakraborty A*. (2003) The murine myeloid cell line 32Dcl3 as a model system for studying neutrophil functions. J. Immunol. Methods. 283(1-2): 195-204.    

Review Articles

  1. Chauhan N, Gaur KK, Asuru TR, Guchhait P* (2024) Dengue virus: pathogenesis and potential small molecule antivirals. Bioscience Reports, 44 BSR20240134; https://doi.org/10.1042/BSR20240134. 
  2. Joshi G, Das A, Verma G, Guchhait P* (2023) Viral infection and host immune response in diabetes. IUBMB Life, DOI: 10.1002/iub.2794.
  3. Shrimali MN, Agarwal S, Tiwari A, Guchhait P* (2022) Platelet-Neutrophil interactions and thrombo-inflammatory complications in type-2 diabetes mellitus. Current Physiology Reports, 10:1-10.
  4. Bhattacharya S, Agarwal S, Shrimali SM and Guchhait P* (2021) Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases. Molecular Aspects of Medicine. 81:101000
  5. Singh A, Bisht P, Bhattacharya S, Guchhait P*. (2020) Role of platelet cytokines in Dengue virus infection. Frontiers in Cellular and Infection Microbiology, 10:561366
  6. Batra H, Chawla S, Singhal R, Annarapu GK, Guchhait P*.  (2016) Cell free hemoglobin modulates phenotype and function of immune cells in hemolytic disorders. Austin Hematology, 1(1): 1007. 
  7. Bhattacharya S, Bhasym A, Guchhait P*. (2016) Insights into Cardiovascular Diseases: The Vicious Platelet-Immune System Loop. Cardiology: Open Access, 1(1):1-7. 
  8. Annarapu GK, Singhal R, Chawla S, Ojha A, Guchhait P*. (2016) Hemoglobin mediated regulation of platelet functions. Journal of Hematology and Transfusion, 4(3): 1052. 
  9. Pandey A, Chawla S, Guchhait P*. (2015) Type-2 diabetes: Current understanding and future perspectives. IUBMB Life. 67:506. 
  10. Chawla S., Singhal R., Guchhait P*. (2014) Hypertension in hypoxia. Hypertension Cardiol. 1 (3): 1-16.
  11. Zhou Z, Yee D, Guchhait P*. (2012) Molecular link between intravascular hemolysis and vascular occlusion in sickle cell disease. Current Vascular Pharmacology. 10(6):756-61. 
  12. Zhou Z, Behymer M, Guchhait P*. (2011) Role of extracellular hemoglobin in thrombosis and vascular occlusion in patients with sickle cell anemia. Anemia. 10.1155/2011/918916. 
  13. Zhou Zhou, Prasenjit Guchhait*. (2010) Extracellular Hemoglobin regulation of von Willebrand factor activity. US Oncology & Hematology, 7(2):150–2. 
  14. Zhou Z*, Nguyen T, Guchhait P, Dong JF*. (2010) Von Willebrand factor, ADAMTS-13, and Thrombotic thronbocytopenic purpura. Seminar in Thrombosis Hemostasis, 36:71-81.  

Book Chapter

  1. Tiwari RL, Annarapu GK, Guchhait P*. (2013) Pathophysiological consequences of hemolysis in sickle cell disease in "Sickle Cell Disease" (Ed. D Acuna-Costroviejo and I Rusanova). Nova Science Publishers, Inc. ISBN: 978-1-62618-774-0.
  1. Follow of National Academy (FNA), India
  2. Doctor of Science (D.Sc.), Banaras Hindu University, India
Dr. Prasenjit Guchhait
Professor

Regional Centre for Biotechnology
NCR Biotech Science Cluster
3rd Milestone, Faridabad-Gurgaon Expressway
P.O. Box No. 3, Faridabad - 121 001
Haryana (NCR Delhi), India
E-mail: prasenjit at rcb dot res dot in
Phone: 91 129-2848821

no text prasenjit[at]rcb[dot]res[dot]in
no text 91 129-2848821

Dr. Prasenjit Guchhait

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