Ojha D. Rode A (2024)
Rational development of FMN-based orthogonal riboswitch that functions in response to specific non-cognate ligand, Research Square https://doi.org/10.21203/rs.3.rs-4276382/v1
2024
2024
2024
2024
P. Yadav, K. Rana, V. Nardini, A. Khan, T. Pani, A. Kar, D. Jain, R. Chakraborty, R. Singh, S. K. Jha, D. Mehta, H. Sharma, R. D. Sharma, SVS Deo, S. Sengupta, V. S. Patil, L. H. Faccioli, U. Dasgupta, and A. Bajaj*
“Engineered Nanomicelles Inhibit the Tumor Progression via Abrogating the Prostaglandin-mediated Immunosuppression.” J. Controlled Release 2024, 368, 548-565.
Prajapat, S.K., Mishra L, Khera S, Osuwu S, Ahuja K, Choudhary E, Chhabra E, Singh R, Kaushal PK, Mahajan D, Banerjee A, Motiani R, Vrati S, Kalia M (2024)
“Methotrimeprazine is a neuroprotective antiviral in JEV infection via adaptive ER stress and autophagy”.
EMBO Mol Med. 2024 Jan;16(1):185-217. doi: 10.1038/s44321-023-00014-w. Epub 2024 Jan 2.
Sharma KB, Subramani C, Ganesh K, Sharma A, Basu B, Balyan S, Sharma G, Shouri KA, Deb A, Srivastava M, Chugh S, Sehrawat S, Bharadwaj K, Rout A, Sahoo. PK, Saurav S, Motiani RK, Singh R, Jain D, Asthana S, Wadhwa R, and Vrati S.
Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection.
PLoS Pathog. 2024 (in press)
Deb A, Nagpal S, Yadav RK, Thakur H, Nair D, Krishnan V, Vrati S.
Japanese encephalitis virus NS5 protein interacts with nucleolin to enhance the virus replication.
J Virol. 2024 Aug 20;98(8):e0085824. doi: 10.1128/jvi.00858-24. Epub 2024 Jul 30.
Tanwar J, Ahuja K, Sharma A, Sehgal P, Ranjan G, Sultan F, Agrawal A, D’Angelo, Priya A, Yenamandra VK, Singh A, Raffaello A, Madesh M, Rizzuto R, Sivasubbu S and Motiani RK# (2024).
Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments. PLoS Biology 2024 Nov 11;22(11):e3002895
Kalita, B., S. Sahu*., A. Bharadwaj*., L. Panneerselvam., G. Martinez-Cebrian., M. Agarwal., and S.J. Mathew. 2024.
The WNT-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma. Oncogene 43: 524-538 (2024). doi: 10.1038/s41388-023-02911-3.
Singh D, Zhao H, Gupta SK, Kumar Y, Kim J, Pawar PA-M.
Characterization of Arabidopsis eskimo1 reveals a metabolic link between xylan O-acetylation and aliphatic glucosinolate metabolism. Physiologia Plantarum (2024).
7D, a promising antiviral small molecule drug against dengue
Prof. Prasenjit Guchhait’s lab in Regional Centre for Biotechnology, Faridabad, India, has developed a promising antiviral drug for dengue treatment in collaboration with Dr. Shailendra Asthana’s lab in Translational Health Science and Technology Institute, Faridabad. The study was published recently by Gaur KK and Asuru TR et al in the reputed journal EMBO Molecular Medicine.
Nucleolin helps in JEV replication through GQ
Japanese Encephalitis virus (JEV) is endemic in most parts of South-East Asia and the Western Pacific region, causing epidemics of encephalitis with a high case fatality rate. While a tissue culture-derived JEV vaccine is available, no antiviral therapy exists. The JEV NS5 protein has RNA-dependent RNA polymerase activity. Together with several host and viral proteins, it constitutes the replication complex necessary for virus replication. Investigating NS5’s interactions with host proteins offers potential avenues for antiviral development.
