Jayeeta Bhaumik (CIAB), Sudhanshu Vrati (RCB), Yeddula Nikhileshwar Reddy (CIAB), Sanjam Chandna (CIAB), Shatabdi paul (CIAB), Ravneet Kaur (CIAB), Shubhra Agarwal (RCB) and S Chandru (RCB) (7 May 2021). Polypyrroles are promising candidates for the generation of reactive oxygen species (ROS). However, these macromolecules lack hydrophilicity which make them difficult for applications in biological systems. To overcome this water insolubility issue, polypyrroles can be loaded into various lignin based nanomaterials via entrapment or conjugation. Lignin based nanomaterials are biocompatible and can serve as a great platform for the delivery of the bioactive agents including polypyrroles. Therefore, the polypyrroles, the lignin nanomaterials, and the polypyrrole loaded lignin nanoformulations are subjected to cytotoxicity as well as antiviral efficacy study against SARS-CoV-2 cell lines.