Nidhi Adlakha and Shivam Aggarwal, Sathish Dorairaj (31 August 2022) Indian Patent Application No. 202211049822 An objective of the invention is to provide a method for enhancing the production of cellulase production in Talaromyces cellulolyticus. Further, the invention provides a culture media composition for enhancing the production of cellulase in Talaromyces cellulolyticus comprising Inducers present in the total concentration of 17.5mM comprising Cellobiose present in the concentration of 12.5mM and the Gentiobiose present in the concentration of 5mM. Another objective of the invention is to provide a omics based method of identifying the inducer molecules for promoting the cellulase production in Talaromyces cellulolyticus.