Figure: (A) Domain organization of ApPol1 
(B) Crystal structure of ApPol1 and 
(C) Computational model of DNA-bound structure of ApPol1.
Replication of the genome is carried out high fidelity DNA polymerases in all organisms. The DNA polymerases are classified into seven families among which the A, B, C and D families are composed of high fidelity enzymes that are responsible for chromosome duplication.

Rhabdomyosarcoma (RMS) is a soft tissue cancer that occurs predominantly in children and adolescents. RMS tumor cells resemble skeletal muscle cells. However, unlike normal skeletal muscle cells which undergo terminal differentiation, RMS tumor cells do not differentiate. The ability to remain undifferentiated could underlie the tumor-specific properties such as proliferation and metastasis in RMS. In this study, we identify the Wnt-pathway as a target signaling cascade that can promote RMS tumor cell differentiation.