Proposed model explaining changes in different metabolites in eskimo1 compared to wild type: The xylan hypo-acetylation in the eskimo1 inflorescence stem may cause increased soluble acetate that can induce the synthesis of the phytohormones JA. JA can further induce aliphatic GSL accumulation and reduce methionine levels (indirectly). Lower levels of isothiocyanates could be because of major reprogramming in GSL metabolism.

This study reveals a critical role of mitochondrial calcium (Ca2+) uptake in vertebrate pigmentation. The authors identify that the mitochondrial Ca2+ uniporter (MCU) complex plays a crucial role in driving skin pigmentation. Finally, they highlight the therapeutic potential of targeting MCU to treat pigmentary disorders.